Windowed Green Function Method for Nonuniform Open-Waveguide Problems

This contribution presents a novel Windowed Green Function (WGF) method for the solution of problems of wave propagation, scattering and radiation for structures which include open (dielectric) waveguides, waveguide junctions, as well as launching and/or termination sites and other nonuniformities. Based on use of a "slow-rise" smooth-windowing technique in conjunction with free-space Green functions and associated integral representations, the proposed approach produces numerical solutions with errors that decrease faster than any negative power of the window size. The proposed methodology bypasses some of the most significant challenges associated with waveguide simulation. In particular the WGF approach handles spatially-infinite dielectric waveguide structures without recourse to absorbing boundary conditions, it facilitates proper treatment of complex geometries, and it seamlessly incorporates the open-waveguide character and associated radiation conditions inherent in the problem under consideration. The overall WGF approach is demonstrated in this paper by means of a variety of numerical results for two-dimensional open-waveguide termination, launching and junction problems.Comment: 16 Page

Windowed Green Function method for layered-media scattering

This paper introduces a new Windowed Green Function (WGF) method for the numerical integral-equation solution of problems of electromagnetic scattering by obstacles in presence of dielectric or conducting half-planes. The WGF method, which is based on use of smooth windowing functions and integral kernels that can be expressed directly in terms of the free-space Green function, does not require evaluation of expensive Sommerfeld integrals. The proposed approach is fast, accurate, flexible and easy to implement. In particular, straightforward modifications of existing (accelerated or unaccelerated) solvers suffice to incorporate the WGF capability. The mathematical basis of the method is simple: the method relies on a certain integral equation posed on the union of the boundary of the obstacle and a small flat section of the interface between the penetrable media. Numerical experiments demonstrate that both the near- and far-field errors resulting from the proposed approach decrease faster than any negative power of the window size. In the examples considered in this paper the proposed method is up to thousands of times faster, for a given accuracy, than a corresponding method based on the layer-Green-function.Comment: 17 page

Preneoplastic somatic mutations including MYD88(L265P) in lymphoplasmacytic lymphoma

Normal cell counterparts of solid and myeloid tumors accumulate mutations years before disease onset; whether this occurs in B lymphocytes before lymphoma remains uncertain. We sequenced multiple stages of the B lineage in elderly individuals and patients with lymphoplasmacytic lymphoma, a singular disease for studying lymphomagenesis because of the high prevalence of mutated MYD88. We observed similar accumulation of random mutations in B lineages from both cohorts and unexpectedly found MYD88(L265P) in normal precursor and mature B lymphocytes from patients with lymphoma. We uncovered genetic and transcriptional pathways driving malignant transformation and leveraged these to model lymphoplasmacytic lymphoma in mice, based on mutated MYD88 in B cell precursors and BCL2 overexpression. Thus, MYD88(L265P) is a preneoplastic event, which challenges the current understanding of lymphomagenesis and may have implications for early detection of B cell lymphomas

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Windowed Green Function MoM for Second-Kind Surface Integral Equation Formulations of Layered Media Electromagnetic Scattering Problems

This paper presents a second-kind surface integral equation method for the numerical solution of frequency-domain electromagnetic scattering problems by locally perturbed layered media in three spatial dimensions. Unlike standard approaches, the proposed methodology does not involve the use of layer Green functions. It instead leverages an indirect Müller formulation in terms of free-space Green functions that entails integration over the entire unbounded penetrable boundary. The integral equation domain is effectively reduced to a small-area surface by means of the windowed Green function method, which exhibits high-order convergence as the size of the truncated surface increases. The resulting (second-kind) windowed integral equation is then numerically solved by means of the standard Galerkin method of moments (MoM) using RWG basis functions. The methodology is validated by comparison with Mie-series and Sommerfeld-integral exact solutions as well as against a layer Green function-based MoM. Challenging examples including realistic structures relevant to the design of plasmonic solar cells and all-dielectric metasurfaces, demonstrate the applicability, efficiency, and accuracy of the proposed methodology

Combined field-only boundary integral equations for PEC electromagnetic scattering problem in spherical geometries

International audienceWe analyze the well posedness of certain field-only boundary integral equations (BIE) for frequency domain electromagnetic scattering from perfectly conducting spheres. Starting from the observations that (1) the three components of the scattered electric field $\mathbf{E}^s(\mathbf{x})$ and (2) scalar quantity $\mathbf{E}^s(\mathbf{x})\cdot\mathbf{x}$ are radiative solutions of the Helmholtz equation, novel boundary integral equation formulations of electromagnetic scattering from perfectly conducting obstacles can be derived using Green's identities applied to the aforementioned quantities and the boundary conditions on the surface of the scatterer. The unknowns of these formulations are the normal derivatives of the three components of the scattered electric field and the normal component of the scattered electric field on the surface of the scatterer, and thus these formulations are referred to as field-only BIE. In this paper we use the Combined Field methodology of Burton and Miller within the field-only BIE approach and we derive new boundary integral formulations that feature only Helmholtz boundary integral operators, which we subsequently show to be well posed for all positive frequencies in the case of spherical scatterers. Relying on the spectral properties of Helmholtz boundary integral operators in spherical geometries, we show that the combined field-only boundary integral operators are diagonalizable in the case of spherical geometries and their eigenvalues are non zero for all frequencies. Furthermore, we show that for spherical geometries one of the field-only integral formulations considered in this paper exhibits eigenvalues clustering at one -- a property similar to second kind integral equations